李继喜（教授）

研究抗感染天然免疫应答及肿瘤免疫相关蛋白质复合物的结构基础与功能机制。包括：1，细胞程序性坏死及炎症反应相关蛋白的结构生物学研究；2，天然免疫应答与神经退行性疾病交互调控的分子机制。

在Cell、Immunity、Annu Rev Immunol、PNAS等期刊上发表40余篇SCI论文，申请/授权发明专利11项。主持及参加的科研项目包括国家重点研发计划（2016YFA0500600）、科技部重大研究计划（2015CB943300）及国家自然科学基金面上项目（31470724、31670878）等。

国家重点研发计划“蛋白质机器与生命过程调控”首席科学家（2016）；复旦大学复星医药奖教金（特等奖）（2016）；上海市“东方学者”特聘教授（2014）；哈佛大学华人生命科学年度杰出研究奖（2013）；国家留学基金委惠普奖学金（2005）。

1. Kleino A, Ramia N, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H*,Li J*, Silverman N*. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-kB Signaling.Immunity2017 Oct 17; 47:635-647

2. Kuang S, Zheng J, Yang H, Li S, Duan S, Shen Y, Ji C, Gan J, Xu XW,Li J*. Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis.Proc Natl Acad Sci U S A. 2017 Sep 19. pii: 201708194. doi: 10.1073/pnas.1708194114.

3. Huo YY, Li S, Huang J, Rong Z, Wang Z, Li Z, Ji R, Kuang S, Cui HL,Li J*, Xu XW*. Crystal structure of Pelagibacterium halotolerans PE8: New insight into its substrate-binding pattern.Sci Rep.2017 June 30;7: 4422. doi:10.1038/s41598-017-04550-7

4. Cao X, Li C, Xiao S, Tang Y, Huang J, Zhao S, Li X,Li J, Zhang R, Yu W. Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage.Proc Natl Acad Sci U S A.2017 Jan 24;114(4):687-692.

5. Huang J, Huo YY, Ji R, Kuang S, Ji C, Xu XW*,Li J*.Structural insights of a hormone sensitive lipase homologue Est22.Sci Rep.2016 Jun 22;6:28550. doi: 10.1038/srep28550.

6. Yin Q, Fu T,Li J*,Wu H*. Structural Biology of Innate Immunity.Annu Rev Immunol.2015 Mar 21;33:393-416.

7.Li J, Yin Q, Wu H. Structural basis for TNFR mediating signal pathways.Adv Immunol.2013;119:135-53.

8. Lee J, Yi L,Li J, Schweitzer K, Borgmann M, Naumann M, Wu H. Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1.Proc Natl Acad Sci U S A.2013 Jul 16;110(29):11845-50.

9.Li J, McQuade T, Siemer A, Napetschnig J, Damko E, Hsiao Y, Moquin D, Walz T, Mcdermott A, Chan FK, Wu H. The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis.Cell2012 Jul 20;150(2):339-50. (Highlighted by Nature Reviews Molecular Cell Biology 2012 Aug 1;13(9):540-1)

10.Li J, Wei Z, Zheng M, Gu X, Deng Y, Qiu R, Chen F, Ji C, Gong W, Xie Y, Mao Y. Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2) in complex with GMP.J Mol Biol.2006, 355(5):980-988